Ous Staff - Cell Factory Policlinico Milano

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Ous Staff

Our Staff
Lorenza Lazzari
R&D Director
Scientific researcher, coordinator and supervisor of all experimental works principal investigator in most national and international research programs related to basic and clinical research on stem cells. Her research laboratory is involved in studies on human hematopoietic and mesenchymal stem cells from different sources (cord blood, adipose tissue, amniotic fluid, tooth, muscle, etc..), particularly in terms of isolation, expansion, characterization and differentiation of these cells and their ability to repair damaged tissues.
Member of the Scientific Committee of Fondazione IRCCS Ca’ Ga Granda Ospedale Maggiore Policlinico di Milano and President of Forum of Italian Researchers on Mesenchymal and Stromal Stem Cells – FIRST.
Rosaria Giordano
Qualified Person
Technical Director of the hospital based GMP facility Cell Factory, specialized in the production of cellular products for clinical use. The facility has been accredited for cellular therapy production by the Italian Agency for medicinal products evaluation (AIFA). The facility is involved in several sponatenous clinical experimental protocols for hematological, cardiologic and neurologic diseases. The facility can provide the following cell-based products: CD133+ and CD34+ cells from bone marrow and peripheral blood, ex-vivo expanded cord blood-derived hematopoietic progenitors, cord blood-derived and adipose tissue-derived mesenchymal stem cells.

Tiziana Montemurro
Role: Director of Production of the hospital based GMP Facility Cell Factory.
Activity: Senior Research associated in Cell Factory’s Group since January 2000, specialized in the production of cellular products for clinical use according to the requirements of Good Manufacturing Practice, such as clinical grade selection and expansion of Bone Marrow/ Cord Blood Mesenchymal Stem Cells, or clinical grade selection and ex vivo expansion of CD34+ and CD133+ Cord Blood Stem Cells.
Previously: M.SC. in Biology at University of Milan, Title of experimental thesis: “Ex vivo expansion of hematopoietic stem cells from cord blood”  (1999); Visiting scientist at the Research Unit of Prof. B. Peault -U506 Groupe Hospitalier Paul Brousse Villejuif, France (2002); Post academic graduate in Medical Genetics (2009).
Mariele Vigano
Role: since October 2011 Responsible for Quality Control in the GMP facility “Cell Factory F. Calori” 
Activity: Post-Doctoral Fellow in Cell Factory’s Group since 2008 working on GMP activities concerning quality control of cellular products for clinical use: set up and performing assays in accordance to standard operating procedures (SOP); writing SOP and work instructions, analyzing data and actively participating in new methods development and validation.
Since 2009 admitted to the five-year specialty school program in Clinical  Biochemistry.
Previously: PhD in Neuroscience in December 2007 at the Department of Neuroscience and Biomedical Technologies, University of Milan- Bicocca, Monza (Italy).
Research experience in Belgium during the third year of PhD program.
BSc in Biology at the University of Milan-Bicocca (Italy) in April 2005.
Elisa Montelatici
Role: working in Cell Factory’s Group since April 2004, principally involved in Good Manifacturing Practice cell processes. Since 2010 she his responsible for the storage and distribution of final products processed in our GMP facility. She is also in charge of the supervision of the external quality control laboratories for the cellular product release testing.
Activity: senior researcher involved in clinical grade production of Mesenchymal Stem Cells, isolation and expansion, from different sources (Bone Marrow and Cord Blood) and selection of Mobilized Peripheral Blood Stem Cells by immunomagnetic positive selection system.  Her special interest in GMP is developing efficient tools for the trend analysis of the manufacturing processes in order to continuously improve the quality of the cellular products.
Previously: graduate in Biotechnology since 2003, University of Milano, and post academic graduate in Clinical Biochemistry since 2010, specialty school at University of Pavia.
Cristiana Lavazza
RRole: Post-Doctoral Research Associate
GMP (Good Manufacturing Practices) Qualified Scientist 
Activity: In Cell Factory’s R&D Group since 2010, she investigates isolation, characterization and cryopreservation of mesenchymal stem cells from different sources. 
At Cell Factory’s GMP Facility since 2010, she exerts in both Production and Quality Control of cellular therapeutic products from aphaeresis, bone marrow and cord blood. 
She is attending a 2nd level post graduate School in Clinical Biochemistry. 
Previously: Post-Doctoral Research Associate at the National Cancer Institute (Istituto Nazionale Tumori) in Milano, Italy, working on translational cellular and gene therapy approaches [2005-2009]. 
Ph.D. in Biotechnology Applied to Medical Sciences at Università degli Studi, Milano, Italy, with a doctoral thesis Use of genetically-engineered TRAIL-expressing stem cells as a treatment for disseminated lymphomas” (“Uso di cellule staminali geneticamente modificate ad esprimere TNF-Related Apoptosis Inducing Ligand (TRAIL) per il trattamento di linfomi disseminati”) [2002-2005]. 
M.Sc. with honors in Medical Biotechnology at Università degli Studi, Milano, Italy, with the thesis Use of chimeric adeno-retriviral vectors for in vitro transduction of hematopoietic and non-hematopoietic cells” (“Uso di vettori chimerici adeno-retrovirali per la trasduzione in vitro di cellule emopoietiche e non-emopoietiche”) [1997-2002]. 
Enrico Ragni
Role: Post-Doctoral Research Associate
Activity: Study of molecular responses induced during the expansion and differentiation of mesenchymal stem cells. DNA, mRNa and microRNA analysis and comparison in stem cells from different sources.
Previously: Graduated in 2001 in Biological Sciences with magna cum laude (University of Milan, Italy). Habilitation for the Biologist profession acquired in 2002. PhD in Cellular and Molecular Biology (vote: Excellent) in 2005 (University of Milan). From 2004 to 2006 he worked as PostDoc at the HIP Department of Heidelberg University (Heidelberg, Germany) with a grant for Promising Young Researchers (University of Milan) and a fellowship founded by EC (FP6 Life Sciences-Fungwall Project). From 2006 to 2011 he held the position of Research Fellow at University of Milan. In 2007 he was awarded a FEMS Young Scientist Scientific Grant. He held a teaching position in the course “Laboratory of Experimental Biology II” from 2002 to 2004 and from 2006 to 2010 (University of Milan). From 2011 he works at Cell Factory Milano with fellowships founded by EC (FP7 Health-Cascade and Reborne Projects).
Mario Barilani
Role: Junior researcher.
Activity: Research Fellow in Cell Factory's Group since October 2011 investigating umbilical cord blood-derived mesenchymal stem cells (CBMSC). The research project includes: isolation, long-term culture maintenance, differentiation, interaction with biomaterials, and reprogramming to pluripotency, of CBMSC.
Previously: M.Sc. in Genetics and Molecular Biology, University of Rome "La Sapienza" [2008-2010]; B.Sc. in Biotechnology, University of Milano-Bicocca [2005-2008].
Silvia Budelli
Role: GMP qualified operator.
Activities: Junior researcher in Cell Factory’s group since December 2011, principally involved in document management and clinical grade cell processes (isolation and expansion of mesenchymal stem cells from different sources, CD133+ and CD34+ enrichment from mobilized peripheral blood or bone marrow using immunomagnetic selection system).
Previously: M.Sc. in Pharmaceutical Biotechnology at University of Milan, with the thesis “Critical aspects of microbial contamination of skin tissue for transplantation purposes: experience of the Lombardy Region Tissue Bank”. B.Sc. in Pharmaceutical Biotechnology at University of Milan, after a one-year internship at the Laboratory of Pharmacology of Thrombosis and Atherosclerosis of the Department of Pharmacological Sciences, University of Milan and the thesis “Terutroban, a thromboxane/prostaglandin endoperoxide receptor antagonist, prevents hypertensive vascular hypertrophy and fibrosis in spontaneously hypertensive rats stroke-prone (SHR-SP)”. 
Federica Banfi
Role: Junior research fellow in Cell Factory’s group since January 2016.
Previously: M.Sc. in Molecular Biology of the Cell with a thesis on “mRNA cargo di microvescicole extracellulare secrete da cellule staminali mesenchimali umane nel paradigma della comunicazione intercellulare”. External supervisor: Prof. Caterina La Porta, Internal supervisor: Dr. Enrico Ragni.
Federica Banfi
Student, Uiversity of Milan
Federica Banfi
Student: Uiversity of Trieste
Angela Genicco
Student: University of Milano Bicocca
Maria Luisa Persivate
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